本研究的主要目的,是对具有慢性稳定型心绞痛,但未曾发生过心肌梗塞(MI)的患者,服用阿斯匹林或安慰剂作出多中心试验对比研究。方法:2 035例年龄30～80岁具有至少1月运动性胸痛病史、慢性稳定型心绞痛症状的患者,口服索他洛尔,剂量逐渐递增至症状得到最佳控制。中位剂量为每日160mg(40～480mg)。3周后,若患者对索他洛尔的耐受情况良好,则用双盲法随机分配服用阿斯匹林(75mg/日,1 009例)或同等剂量的安慰剂(1026例)。中位追踪时间为50个月(23～76个月)。服药过程允许有4周短暂中断。结果:追踪期结束时,主要终点事件(首发非致命性MI、致命性MI及猝死)者计205例(阿斯匹林 The primary objective of this study was to conduct a multicenter trial comparing aspirin or placebo in patients with chronic stable angina but without myocardial infarction (MI). METHODS: A total of 2 035 patients 30 to 80 years of age with at least 1-month history of exercise-induced chest pain and symptoms of chronic stable angina were treated with oral sotalol, and the dose was gradually increased until symptoms were optimally controlled. The median dose of 160mg daily (40 ~ 480mg). After 3 weeks, patients were randomized to aspirin (75 mg / day, 1 009) or placebo (1026 patients) if they were well tolerated with sotalol. The median follow-up time was 50 months (23-76 months). The medication process allowed a brief interruption of 4 weeks. RESULTS: At the end of the follow-up period, 205 patients (aspirin, primary aspirin, non-fatal MI, sudden death)