论文部分内容阅读
目的分析糖耐量异常(IGT)患者的尿微量白蛋白(MAU)、同型半胱氨酸(Hcy)和颈动脉内膜中层厚度(CIMT)之间的关系。方法收集本科室接收的患IGT的66例患者,按照其颈动脉超声检查结果,将CIMT≤10mm的22例患者分为研究A组,>10mm的44例患者分为研究B组。同时取同期于本院进行健康体检的50例正常人群作为参考组。观察3组的血清Hcy与AMU水平,且对其与CIMT增厚的相关性进行分析。结果研究A组、B组的MAU、Hcy水平与参考组相比明显更高,其中又以研究B组的指标水平显著更高(P<0.05)。通过Logistic回归分析发现,Hcy(OR值为1.099,P<0.05)与MAU(OR值为4.342,P<0.05)均为CIMT增厚的危险因素。结论 IGT患者的MAU、Hcy水平和CIMT增厚呈正相关关系,临床应提高重视。
Objective To analyze the relationship between urinary microalbumin (MAU), homocysteine (Hcy) and carotid intima-media thickness (CIMT) in patients with impaired glucose tolerance (IGT). Methods Totally 66 patients with IGT were enrolled in this department. According to their results of carotid ultrasound, 22 patients with CIMT≤10mm were divided into study group A and 44 patients> 10mm into study group B. At the same time take the same period in our hospital for physical examination of 50 normal subjects as a reference group. Serum Hcy and AMU levels were observed in 3 groups, and their correlations with CIMT thickening were analyzed. Results The levels of MAU and Hcy in group A and group B were significantly higher than those in reference group, and those in group B were significantly higher (P <0.05). Logistic regression analysis showed that Hcy (OR = 1.099, P <0.05) and MAU (OR = 4.342, P <0.05) were all risk factors for CIMT thickened. Conclusion The levels of MAU and Hcy in patients with IGT are positively correlated with the thickening of CIMT, and should be paid more attention in clinical practice.