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植入电极是植入电刺激器的一个重要部件,为了降低植入电极的阻抗和减少组织的炎性反应,本文针对植入电极界面的特性要求,采用逐层修饰的方法,先用电化学方法在铂-铱合金微电极(d=75μm)上沉积氧化铱,然后在绝缘封装材料硅橡胶上接枝一层高分子涂层聚乙烯醇/聚丙烯酸(PVA/PAA).经修饰的微电极植入大鼠大脑运动皮层运动区一个月,在第21天测量其电极阻抗.结果初步显示逐层修饰的电极阻抗降低了53%.行为学评价显示电极在植入大鼠运动皮层后没有对大鼠的运动行为产生不良影响.
In order to reduce the impedance of implanted electrodes and reduce the inflammatory reaction of the tissue, implanted electrodes are an important part of implanted electrical stimulator. In order to reduce the tissue inflammatory response, Methods Iridium oxide was deposited on the platinum - iridium microelectrode (d = 75μm), and then a layer of polymer coating polyvinyl alcohol / polyacrylic acid (PVA / PAA) The electrodes were implanted into the motor cortex of the rat brain for one month and the impedance of the electrodes was measured on the 21st day.The results showed that the impedance of the layer-by-layer modified electrode was reduced by 53% .A behavioral evaluation showed that there was no electrode after the implanted rat motor cortex Have adverse effects on motor behavior in rats.