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本文研究了Epostane抗早孕的临床效果。Epostane能抑制孕酮的合成。作用机制为竞争抑制3β-羟基甾体脱氢酶的活性,从而阻断孕烯醇酮转化为孕酮。作者在早孕妇女应用Epostane达到终止早孕的目的。 56例健康妇女,年龄在21～41岁( ±SD:30.4±5.9)停经天数为±SD:45.4±5.4天(从末次月经算起),本人要求终止妊娠。以往无肝、肾、肾上腺、肠胃道疾病以及无反复自然流产及不正常的生育史者被征集为试验对象。用药前必须作
This article studies the clinical efficacy of Epostane in preventing pregnancy. Epostane inhibits progesterone synthesis. The mechanism of action is to inhibit the activity of 3β-hydroxy steroid dehydrogenase, thereby blocking the conversion of pregnenolone to progesterone. The authors use Epostane in early pregnant women to achieve the purpose of termination of early pregnancy. Fifty-six healthy women, 21 to 41 years of age (± SD: 30.4 ± 5.9), had a median menopause of ± SD: 45.4 ± 5.4 days from the last menstrual period, and I requested termination of pregnancy. Past no liver, kidney, adrenal, gastrointestinal diseases and no recurrent spontaneous abortion and abnormal birth history were collected as the test object. Must be done before medication