女,43岁。因患过敏性哮喘入院,给予口服氨茶碱0.2Q6h,测定茶碱最低血清浓度为8.45μg/ml已达稳态,哮喘得到控制。后因继发感染,给予口服螺旋霉素,0.2Q6h。4天后,患者出现恶心、呕吐。测茶碱最低血清浓度达21.88μg/ml。停服氨茶碱12小时后改用青霉素、链霉素。继续按上述剂量和用法,给予口服氨茶碱,随访一个多月,患者未再出现恶心、呕吐等症。笔者认为,患 Female, 43 years old. Due to allergic asthma admitted to give oral aminophylline 0.2Q6h, the determination of theophylline minimum serum concentration of 8.45μg / ml has reached steady state, asthma was controlled. After secondary infection, given oral spiramycin, 0.2Q6h. Four days later, the patient developed nausea and vomiting. Theophylline minimum serum concentration of 21.88μg / ml. Stop taking aminophylline 12 hours later switched to penicillin, streptomycin. Continue to press the above dose and usage, given oral aminophylline, follow-up more than a month, the patient no longer nausea, vomiting embolism. I think, suffering