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p38丝裂原活化蛋白激酶(p38 MAPK)信号转导通路是细胞信息传递的交汇点或共同通路,在应激、炎性反应、细胞凋亡、细胞内蛋白质合成与分泌、细胞分化等过程中发挥重要作用。该通路在糖尿病肾脏疾病(DKD)时被激活,通过影响细胞因子的生成、促进细胞凋亡、影响葡萄糖转运蛋白的表达而促进DKD的形成和发展。DKD时,p38 MAPK抑制剂具有保护肾脏的作用,因此将p38 MAPK通路作为DKD治疗的新靶点可能具有重要的临床意义。
The p38 mitogen-activated protein kinase (p38 MAPK) signal transduction pathway is the meeting point or common pathway of cell information transmission. In the process of stress, inflammatory reaction, apoptosis, intracellular protein synthesis and secretion, cell differentiation, etc. Play an important role. The pathway is activated in diabetic nephropathy (DKD), which can promote the formation and development of DKD by affecting the production of cytokines, promoting apoptosis and affecting the expression of glucose transporter. At DKD, p38 MAPK inhibitors have the potential to protect the kidneys, so using the p38 MAPK pathway as a new target for DKD therapy may have important clinical implications.