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目的 :研究肾癌组织中环氧化酶 2 (COX 2 )蛋白的表达 ,探讨COX 2表达与肾癌可能的相关性。方法 :应用免疫组织化学S P法 ,对 4 6例肾癌及其 2 5例癌旁组织COX 2蛋白表达进行检测。结果 :COX 2在 4 6例肾癌组织中的表达阳性百分比为 71 .74 % ,癌旁组织中为 32 .0 0 %。肾癌组织中COX 2表达与癌旁组织相比差异具有统计学意义 (P <0 .0 1 ) ;结论 :COX 2在肾癌组织中表达明显增高 ,与肾癌的发生、发展可能相关 ,有可能作为肾癌诊断的辅助指标之一
Objective: To investigate the expression of cyclooxygenase-2 (COX-2) protein in renal cell carcinoma and to explore the possible relationship between COX-2 expression and renal cell carcinoma. Methods: The immunohistochemical SP method was used to detect the expression of COX-2 protein in 46 cases of renal cell carcinoma and its adjacent tissues. Results: The positive percentage of COX 2 in 46 cases of renal cell carcinoma was 71.74%, and that of adjacent tissues was 32.0%. The expression of COX-2 in renal cell carcinoma tissues was significantly different from that in adjacent non-cancerous tissues (P <0.01). Conclusion: The expression of COX-2 in renal cell carcinoma was significantly increased, which may be related to the occurrence and development of renal cell carcinoma, It may be used as a diagnostic indicator of kidney cancer one of the indicators