目的 :观察芬太尼缓释透皮贴剂 (TDF)作为麻醉辅助药在鼻内镜手术中应用的安全性。方法 :对 30例行鼻内镜手术的患者 ,监测其在贴片前和贴片后 10、2 0、30、6 0min的血压、脉搏、血氧饱和度 ,并将贴片前与贴片后进行比较。同时观察贴片后患者出现恶心、呕吐、食欲不振、皮肤反应及眩晕的发生情况。结果 :贴片后 10、2 0、30、6 0min患者的血压、脉搏、血氧饱和度与贴片前相比较 ,差异无统计学意义 (均P >0 .0 5 )。本组无呕吐、皮肤过敏反应和眩晕者。恶心、食欲不振发生率为13.3% (4 / 30 )。结论 :芬太尼缓释透皮贴剂是一种安全、有效、使用方便的麻醉辅助药。 Objective: To observe the safety of fentanyl sustained-release transdermal patch (TDF) as an anesthetic adjuvant in endoscopic sinus surgery. Methods: Thirty patients undergoing endoscopic sinus surgery were monitored for blood pressure, pulse rate and oxygen saturation at 10, 20, 30 and 60 minutes before and after patch placement. After comparison. At the same time observe the patch after the patient nausea, vomiting, loss of appetite, skin reactions and dizziness. Results: There was no significant difference in blood pressure, pulse rate and oxygen saturation between the two groups after patch placement at 10, 20, 30 and 60 minutes (P> 0.05). This group no vomiting, skin allergies and vertigo. Nausea, loss of appetite was 13.3% (4/30). Conclusion: Fentanyl sustained-release transdermal patch is a safe, effective and convenient anesthetic adjuvant.