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目的 探讨经保留导管区域性动脉灌注化疗胰腺癌的疗效及价值。方法 本文 15例胰腺癌患者 ,采用Seldinger技术经股动脉穿刺插管后 ,将导管先端插进腹腔动脉干 ,然后把导管的体外段盘曲、固定在腹股沟韧带上方。术毕采用ADF方案经保留导管行腹腔动脉干区域性灌注化疗。结果 本文 15例胰腺患者中 ,黄疸完全消退者 8例 ,减轻者 4例 ,总有效率 80 % ( 12 /15 ) ;腹痛症状消失者 9例 ,减轻者 6例。食欲改善及体重有增加者共 12例。生存期 :1,2 ,3年分别为 9例、5例和 3例。结论 本文结果表明 ,对胰腺癌的治疗 ,区域性动脉灌注化疗明显优于全身静脉化疗
Objective To investigate the efficacy and value of preserved ductal regional arterial infusion chemotherapy for pancreatic cancer. Methods 15 patients with pancreatic cancer were treated with femoral artery puncture and cannulation with Seldinger technique. The tip of the catheter was inserted into the celiac artery trunk and then the outer segment of the catheter was coiled and fixed over the inguinal ligament. After the operation, the ADF protocol was used to preserve the catheter for celiac arterial regional infusion chemotherapy. Results Among 15 cases of pancreatic patients, 8 cases of complete remission of jaundice, 4 cases of reduction, the total efficiency of 80% (12/15); 9 cases of abdominal pain symptoms disappeared, 6 cases reduced. There were 12 cases of increased appetite and weight gain. Lifetime: 1, 2, 3 years were 9 cases, 5 cases and 3 cases. Conclusions The results of this study indicate that regional arterial infusion chemotherapy is superior to systemic venous chemotherapy in the treatment of pancreatic cancer.