温热能治疗恶性肿瘤最早的记载是Bush报告1例面部肉瘤由于丹毒发高热而消退。1893年Coley也有相同的报告,后来他从丹毒链球菌中提出Coley氏毒素,以此致热而创始了全身湿热疗法。1898年West-ermark给子宫颈癌病人灌注温水试治有效,称为局部温热疗法。温热疗法历史虽久,但发展缓慢。近年由于实验研究的进展,本疗法作为治疗顽固性癌的对策再次受 The earliest record of warm energy for the treatment of malignant tumors was Bush’s report that 1 facial sarcoma subsided due to erysipelas. Coley also had the same report in 1893. Later, he proposed the Coley’s toxin from Streptococcus megasquamous, which led to the establishment of a systemic damp heat therapy. In 1898, West-ermark was effective in the treatment of cervical cancer patients with warm water, known as local hyperthermia therapy. Although the history of thermotherapy is long, it is developing slowly. In recent years, due to the progress of experimental research, this therapy has been accepted as a treatment for intractable cancers again.