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目的：研究国产洛伐他汀对高脂血症患者血脂代谢的影响。方法：将１２０例患者随机分为洛伐他汀组（ｎ＝８０）及美降之组（ｎ＝４０），分别口服国产洛伐他汀及进口洛伐他汀（美降之），每次２０ｍｇ，每日２次，服用８周。观察用药４周及８周患者血清总胆固醇（ＴＣ）、低密度脂蛋白胆固醇（ＬＤＬ－Ｃ）、高密度脂蛋白胆固醇（ＨＤＬ－Ｃ）、（ＴＣ－ＨＤＬ－Ｃ）／ＨＤＬ－Ｃ、甘油三酯、载脂蛋白ＡⅠ（ＡｐｏＡⅠ）、载脂蛋白Ｂ１００（ＡｐｏＢ１００）及ＡｐｏＡⅠ／ＡｐｏＢ１００变化。结果：服用国产洛伐他汀４周及８周可分别使患者血清ＴＣ降低２３．０％及２７．３％，ＬＤＬ－Ｃ降低２７．９％及３４．１％，高甘油三酯血症患者甘油三酯水平降低２１．６％及２６．２％；ＨＤＬ－Ｃ升高９．１％及１０．１％，（ＴＣ－ＨＤＬ－Ｃ）／ＨＤＬ－Ｃ降低２９．６％及３７．１％。血清ＡｐｏＢ１００降低９．６％及１５．５％，ＡｐｏＡⅠ升高１８．９％及１４．５％，ＡｐｏＡⅠ／ＡｐｏＢ１００升高３９．９％及４４．９％。服药４周即有明显疗效。结论：国产洛伐他汀调血脂作用疗效肯定，与其相应进口产品美降之比较基本相同
Objective: To study the effect of domestic lovastatin on blood lipid metabolism in patients with hyperlipidemia. Methods: One hundred and twenty patients were randomly divided into lovastatin group (n = 80) and trimetazidine group (n = 40). Domestic Lovastatin and lovastatin orally were given orally, 2 times a day, taking 8 weeks. The levels of total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), (TC- HDL- C) / HDL- C, Triester, apolipoprotein A (ApoAI), apolipoprotein B100 (ApoB100), and ApoAI / ApoB100. Results: Taking domestic lovastatin for 4 weeks and 8 weeks respectively, the patients’ serum TC decreased by 23.0% and 27.3%, while the LDL-C decreased by 27.9% and 34.1% respectively. Patients with hypertriglyceridemia Triglyceride levels decreased by 21.6% and 26.2%, HDL-C increased by 9.1% and 10.1%, TC-HDL-C and HDL-C decreased by 29.6% and 37.1 %. Serum ApoB100 decreased 9.6% and 15.5%, ApoA Ⅰ increased 18.9% and 14.5%, ApoA Ⅰ / ApoB100 increased 39.9% and 44.9%. 4 weeks after taking a significant effect. Conclusion: Domestic lovastatin treatment of blood lipid effect is positive, with the corresponding imported products, the United States is basically the same drop