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作者报导了应用放射免疫法对体外循环组和胸内大手术组40例病人进行血浆肾素,血管紧张素Ⅱ和尿缓激肽测定。体外循环(CPB)组于 CPB 后肾素、血管紧张素Ⅱ水平进行性升高,而尿中缓激肽显著降低。这种变化以术后4小时最明显,24小时后逐渐恢复正常,血浆血管紧张素Ⅱ和尿缓激肽相关函数分析表明为负相关(r=-0.8079)。提示血管紧张素Ⅱ,可抑制缓激肽的作用,作者认为肾素—血管紧张素系统和激肽释放酶—激肽系统的变化在 CPB 术中对外周血管收缩及高血压起着重要的作用。
The authors report the use of radioimmunoassay in 40 patients with cardiopulmonary bypass and major thoracic surgery for determination of plasma renin, angiotensin II, and urinary bradykinin. Cardiopulmonary bypass (CPB) group after renovascular renin, angiotensin Ⅱ levels increased, while urinary bradykinin decreased significantly. The change was most obvious at 4 hours after operation and returned to normal after 24 hours. The correlation analysis between plasma angiotensin Ⅱ and urinary bradykinin showed a negative correlation (r = -0.8079). It is suggested that angiotensin II can inhibit the effect of bradykinin. The authors believe that the changes of renin-angiotensin system and kallikrein-kinin system play an important role in peripheral vasoconstriction and hypertension in CPB .