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ｐ２１、ｐ１６及ｐ１５基因所编码的蛋白质能抑制ｃｄｋ激酶的活性，在调控细胞周期方面起重要作用，属肿瘤抑制基因。本研究探讨ｐ２１、ｐ１６及ｐ１５基因突变是否与肾癌及膀胱癌的发生或发展有关。材料与方法肾癌４８例，膀胱癌４２例。点突变检测采用ＳＳＣＰ分析和...
The proteins encoded by the p21, p16 and p15 genes can inhibit the activity of cdk kinase and play an important role in the regulation of the cell cycle and belong to tumor suppressor genes. This study was to investigate whether p21, p16 and p15 mutations are associated with the development of renal cell carcinoma and bladder cancer. Materials and Methods 48 cases of renal cell carcinoma and 42 cases of bladder cancer. Point mutation detection using SSCP analysis and ...