Objective:Laparoscopic gastrectomy has been established as a standard treatment for early gastric cancer,and its use is increasing recently.Compared with the conventional laparoscopy-assisted distal gastrectomy (LADG),totally laparoscopic distal gastrectomy (TLDG) involves intracorporeal reconstruction,which can avoid the additional incision,resulting in pain reduction and early recovery.This study aimed to compare the short-term postoperative outcomes of TLDG vs.LADG in gastric cancer in a high-volume center.Methods:A retrospective cohort study was conducted on 1,322 patients who underwent laparoscopic distal gastrectomy from June 2012 to June 2017 at the National Cancer Center,Korea.LADG was performed in the early period before July 2015,and TLDG was applied in the later period.Postoperative short-term outcomes were compared in terms of complication and clinical course between the two groups.Pain score was measured by rating the pain intensity from 0 to 10 points on postoperative day (POD) 1 and 3.Results:A total of 667 patients underwent LADG and 655 patients underwent TLDG.Clinicopathologic characteristics were not different in both groups.Intraoperative estimated blood loss (EBL) was significantly lower in the TLDG group (P＜0.001).Postoperative pain scores were significantly lower in the TLDG group than in the LADG group on POD 1 (5.1±1.5 vs.4.8±1.4,P=0.015).First flatus passage after operation was significantly earlier in the TLDG group (3.4±0.8 d vs.3.2±0.6 d,P＜0.001).There were no differences in postoperative complications and hospital stay between the two groups.Conclusions:Based on the reported short-term postoperative outcomes,TLDG is safe and feasible as well as LADG.Moreover,compared with LADG,TLDG can reduce intraoperative EBL and postoperative pain and enhance the bowel motility in gastric cancer surgery.