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1前言1.1针对作为接种后不良事件的过敏,制定病例定义与数据收集、分析及描述指南过敏是一种涉及多器官系统的急性超敏反应,可表现为或迅速进展成严重危及生命的反应。过敏可在暴露于多种来源的抗原后发生,包括食品、气源性过敏原、昆虫毒液、药品及预防接种。过敏是由过敏原结合到特异性免疫球蛋白E(IgE)而触发。这提示之前对触发物质或交叉反应过敏原有暴露及致敏。当过敏原结合到肥大细胞及嗜碱性粒细胞表面IgE受体时,会导致细胞活化及
1 Introduction 1.1 Develop case definitions and guidelines for data collection, analysis, and description for allergies as a post-vaccination adverse event Allergy is an acute hypersensitivity reaction involving multiple organ systems that can manifest itself or rapidly progresses into a serious, life-threatening reaction. Allergies can occur after exposure to various sources of antigens, including food, airborne allergens, insect venoms, medicines and vaccinations. Allergy is triggered by allergen binding to specific immunoglobulin E (IgE). This suggests that there was previous exposure and sensitization of triggering substances or cross-reacting allergens. When allergens bind to mast cells and basophil IgE receptors, they cause cell activation and