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目的探讨目标导向液体治疗对腹腔镜卵巢癌根治术患者肝肾功能的影响。方法选取华北理工大学附属医院2013年2月至2015年2月腹腔镜卵巢癌根治术患者142例,分为观察组和对照组,每组71例。对照组实施传统补液方案,观察组实施目标导向液体治疗。记录两组手术时间、术中出血量、术后排气时间、术后进食时间、术后住院时间、体液容量、术后不良反应,检测手术前后谷氨酸氨基转移酶、天门冬氨酸氨基转移酶、清蛋白、直接胆红素、总胆红素、尿素氮、血肌酐水平。结果两组手术前后谷氨酸氨基转移酶、天门冬氨酸氨基转移酶、清蛋白、直接胆红素、总胆红素、尿素氮、血肌酐比较差异有统计学意义(P<0.05)。观察组术后谷氨酸氨基转移酶、天门冬氨酸氨基转移酶、直接胆红素、总胆红素、尿素氮、血肌酐、并发症发生率明显低于对照组(P<0.05),清蛋白明显高于对照组(P<0.05)。观察组术后排气时间、术后进食时间明显早于对照组(P<0.05),术后住院时间、晶体液量、总输入量明显少于对照组(P<0.05),尿量、胶体液量明显多于对照组(P<0.05)。结论与传统补液方案相比,目标导向液体治疗可减轻腹腔镜卵巢癌根治术对患者肝肾功能的影响,提高安全性。
Objective To investigate the effects of targeted therapy on liver and kidney function in patients undergoing laparoscopic radical mastectomy for ovarian cancer. Methods 142 cases of laparoscopic radical mastectomy of ovarian cancer patients from February 2013 to February 2015 in Affiliated Hospital of North China Polytechnic University were selected and divided into observation group and control group with 71 cases in each group. Control group to implement the traditional rehydration program, the observation group implementation of the target-oriented liquid therapy. The operation time, intraoperative blood loss, postoperative exhaust time, postoperative eating time, postoperative hospital stay, body fluid volume and postoperative adverse reactions were recorded. The levels of glutamate aminotransferase, aspartate aminotransferase Transferase, albumin, direct bilirubin, total bilirubin, urea nitrogen, serum creatinine levels. Results Before and after operation, there were significant differences in the levels of glutamate aminotransferase, aspartate aminotransferase, albumin, direct bilirubin, total bilirubin, urea nitrogen and serum creatinine (P <0.05). The incidence of complications in the observation group was significantly lower than that in the control group (P <0.05). The incidence of postoperative complications such as glutamate aminotransferase, aspartate aminotransferase, direct bilirubin, total bilirubin, urea nitrogen, Albumin was significantly higher than the control group (P <0.05). The postoperative exhaust time and postoperative eating time in the observation group were significantly earlier than those in the control group (P <0.05). The postoperative hospital stay, the amount of crystalloid and the total amount of input in the observation group were significantly less than those in the control group (P <0.05) Body fluid was significantly more than the control group (P <0.05). Conclusion Compared with the traditional rehydration regimen, target-directed liquid therapy can reduce the impact of laparoscopic radical mastectomy on liver and renal function and improve the safety of patients.