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目的： 探索糖尿病视网膜病变发生发展的有关因素。方法： 对链脲佐菌素诱导的糖尿病大鼠发病后第４ 、６、１２ 和１６ 周视网膜组织中内皮素１ （ ｅｎｄｏｔｈｅｌｉｎ１ ，ＥＴ１）、环磷酸腺苷（ｃｙｃｌｉｃａｄｅｎｉｎｅ ｍｏｎｏｐｈｏｓｐｈａｔｅ，ｃＡＭＰ） 和环磷酸鸟苷（ｃｙｃｌｉｃｇｕａｎｉｎｅ ｍｏｎｏｐｈｏｓｐｈａｔｅ，ｃＧＭＰ） 的含量进行了检测。结果： 各阶段糖尿病组大鼠视网膜组织中ＥＴ１ 水平明显高于对照组，ｃＡＭＰ含量和ｃＡＭＰ／ｃＧＭＰ比值则明显低于对照组， 随病程延长更为明显，ｃＧＭＰ含量无明显改变。结论：糖尿病视网膜病变的发生和发展可能与高血糖状态下视网膜组织中ＥＴ１ 水平升高所致的视网膜局部微循环功能障碍和代谢紊乱有关。
Objective: To explore the related factors of the development of diabetic retinopathy. Methods: Endostlin1 (ET1), cyclic adenosine monophosphate (cAMP) and nitric oxide synthase (cAMP) in retinal tissue were detected at the 4th, 6th, 12th and 16th weeks after streptozotocin- Cyclic guanosine monophosphate (cyclic guanine monophosphate, cGMP) content was tested. Results: The levels of ET1 in retinal tissue of diabetic rats in each stage were significantly higher than those in control group. The cAMP content and cAMP / cGMP ratio in diabetic rats were significantly lower than those in control group. Conclusion: The occurrence and development of diabetic retinopathy may be related to the retinal microcirculation dysfunction and metabolic disorder caused by elevated ET1 levels in the hyperglycemic retina.