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目的:观察两种分割剂量放疗联合唑来膦酸治疗肺癌骨转移的临床疗效。方法:选择肺癌骨转移70例,随机分为观察组36例和对照组34例。观察组采用高分割放疗,即6MV-X线照射,3Gy/次,5次/周,共30Gy/10次/2周;对照组采用常规分割放疗,照射方式同观察组,剂量为2Gy/次,5次/周,共30Gy/15次/3周。两组均同时给予唑来瞵酸4mg静脉滴注,每4周重复,共4个周期。观察比较两组疼痛缓解率和生存率及不良反应等。结果:治疗结束时,观察组和对照组疼痛缓解率分别为86.1%、79.4%,治疗结束后3个月疼痛缓解率分别为80.6%、73.5%,两组疼痛缓解率比较,差异不显著(P>0.05);观察组和对照组1年生存率分别为44.4%、41.2%,2年生存率分别为11.1%、9.5%,两组生存率比较,差异不显著(P>0.05)。结论:两种不同分割剂量放疗联合唑来瞵酸治疗肺癌骨转移镇痛效果及生存率相似。
OBJECTIVE: To observe the clinical efficacy of two divided doses of radiotherapy and zoledronic acid in the treatment of bone metastasis of lung cancer. Methods: Seventy patients with bone metastasis of lung cancer were randomly divided into observation group (36 cases) and control group (34 cases). The observation group was treated with high-dose radiotherapy, 6MV-X irradiation, 3Gy / time, 5 times / week, a total of 30Gy / 10 times / 2 weeks; control group using conventional radiotherapy irradiation with the observation group, the dose of 2Gy / , 5 times / week, a total of 30Gy / 15 times / 3 weeks. Both groups were given zoledronic acid 4mg intravenous infusion, repeated every 4 weeks, a total of 4 cycles. The pain relief rate, survival rate and adverse reactions of the two groups were observed and compared. Results: At the end of treatment, the pain relief rates of the observation group and the control group were 86.1% and 79.4% respectively. The pain relief rates at 3 months after the end of treatment were 80.6% and 73.5% respectively. There was no significant difference in pain relief between the two groups P> 0.05). The 1-year survival rates of the observation group and the control group were 44.4% and 41.2% respectively, and the 2-year survival rates were 11.1% and 9.5% respectively. There was no significant difference in survival between the two groups (P> 0.05). Conclusion: The two different doses of radiation combined with zoledronic acid in the treatment of lung cancer with bone metastases analgesic effect and survival rate were similar.