论文部分内容阅读
目的:研究白介素-1受体拮抗因子(IL-1RN)基因多态性与强直性脊柱炎(ankylosing spondylitis,AS)的相关性。方法:自150名AS患者及92名健康对照者外周血中提取DNA,采用PCR方法检测IL-1RN基因第二内含子VNTR复等位基因多态性。结果:AS患者中IL-1RN*2等位基因频率显著高于健康对照者。结论:AS与IL-1RN*2等位基因相关联。
Objective: To investigate the relationship between interleukin-1 receptor antagonist (IL-1RN) gene polymorphism and ankylosing spondylitis (AS). Methods: DNA was extracted from peripheral blood of 150 patients with AS and 92 healthy controls. The polymorphism of the second intron VNTR allele of IL-1RN gene was detected by PCR. Results: The frequency of IL-1RN * 2 allele in AS patients was significantly higher than that in healthy controls. Conclusion: AS is associated with the IL-1RN * 2 allele.