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目的:探讨微波辐照对人鼻咽癌细胞丙二醛(MDA)含量和超氧化物歧化酶(SOD)活性的影响。方法:运用微波理疗仪以连续波、垂直极化照射方式对人鼻咽癌细胞CNE-2进行微波辐射(频率2 450 MHz)。实验分为4组:空白对照组,10、20、30 mW/cm2辐照组。采用TBA显色法和改良NBT羟胺法检测微波辐照对人鼻咽癌细胞MDA含量和SOD活性的影响。结果:随着微波剂量的增加,MDA含量较对照组均呈上升趋势,20和30 mW/cm2辐照组MDA含量分别为对照组的1.4倍和3.5倍,2个辐照组与对照组比较差异均有统计学意义(P<0.05或P<0.01);辐照组SOD活性分别为对照组的68.2%、46.2%和36.0%,10 mW/cm2辐照组与对照组相比差异有统计学意义(P<0.05),20和30 mW/cm2辐照组与对照组相比差异均有统计学意义(均P<0.01)。结论:微波辐照可致鼻咽癌细胞MDA含量明显增高,SOD活性降低。
Objective: To investigate the effects of microwave irradiation on the content of malondialdehyde (MDA) and the activity of superoxide dismutase (SOD) in human nasopharyngeal carcinoma cells. Methods: Microwave irradiation was performed on human nasopharyngeal carcinoma cell line CNE-2 (frequency: 2 450 MHz) by using microwave therapy instrument. The experiment was divided into 4 groups: blank control group, 10,20,30 mW / cm2 irradiation group. The effects of microwave irradiation on the content of MDA and the activity of SOD of nasopharyngeal carcinoma cells were detected by TBA colorimetry and modified NBT hydroxylamine method. Results: Compared with the control group, the content of MDA increased with the increase of microwave dose. The MDA content of the irradiated group was 1.4 times and 3.5 times that of the control group at 20 and 30 mW / cm2, respectively (P <0.05 or P <0.01). The SOD activity in the irradiated group was 68.2%, 46.2% and 36.0% respectively compared with the control group. There was statistical difference between the 10 mW / cm2 irradiated group and the control group (P <0.05). There was significant difference between 20 and 30 mW / cm2 irradiation group and the control group (all P <0.01). Conclusion: Microwave irradiation can cause nasopharyngeal carcinoma cells MDA content was significantly increased, SOD activity decreased.