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近年来,临床上已广泛应用造血细胞移植治疗急性白血病、急性再生障碍性贫血等疾病,其治疗急性再生障碍性贫血的成功率约有50％。对急性白血病治疗,也有缓解病例的报告。可是,在造血细胞移植治疗之前必须采取适当措施,使造血细胞能够植入而不致被排斥,在一定程度上也能减轻移植治疗后发生急性免疫反应,这就使我们想到性激素类药物,它是有效的抗辐射药物,对造血可能有一定的影响,在造血细胞移植中是否能产生良好的作用,是值得我们探索的。本文报导了3,17-β棕榈酸雌二醇(简称“棕二”)、丙酸睾丸酮(简称“丙睾”)两类性激素对致死剂量照射Laca小鼠骨髓移植疗效的影响。
In recent years, the clinical application of hematopoietic cell transplantation in the treatment of acute leukemia, acute aplastic anemia and other diseases has been widely used, and the success rate of treating acute aplastic anemia is about 50%. There is also a report on alleviating cases of acute leukemia. However, appropriate measures must be taken prior to the hematopoietic cell transplant to allow the hematopoietic cells to be implanted without rejection and, to a certain extent, reduce the acute immune response after the transplant, which reminds us of sex hormones, which are Effective anti-radiation drugs, may have a certain impact on hematopoiesis, in hematopoietic cell transplantation can produce good effect, it is worth exploring. This article reports the effect of 3,17-β-estradiol palmitate (“Brown II”) and testosterone propionate (“B-testosterone”) on bone marrow transplantation in lethally irradiated Laca mice.