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目的:探讨肢体火器伤中枢神经系统(CNS)应变内环境紊乱的病理生理基础.方法:借助犬双后肢低、高速投射物伤模型,采用RNA斑点杂交、ELISA法,动态观察、定量分析脑组织、脑脊液(CSF)、血清髓鞘碱性蛋白(MBP)表达与释放.结果:伤后8小时血清、CSF、脑组织MBP含量增高(P<0.01),高速组尤甚;低速组下丘脑,高速组下丘脑、海马区MBP-mRNA表达增强(P<0.05).结论:肢体火器伤虽未直接伤及大脑,但提示下丘脑、海马区受损,可能为CNS应变反应的重要病理生理基础之一.
Objective: To investigate the pathophysiological basis of internal environment disorder of central nervous system (CNS) strain in limb firearm injuries. Methods: The low and high speed projectile injury models with double hind limbs were used. The expression and release of MBP in brain tissues, cerebrospinal fluid (CSF) and serum MBP were quantitatively analyzed by RNA dot blot and ELISA. Results: The levels of MBP in serum, CSF and brain tissues increased 8 h after injury (P <0.01), especially in high-speed group. The MBP-mRNA expression in hypothalamus and hippocampus in low-speed group increased significantly (P <0.01). 05). Conclusion: Although limb firearm injury does not directly injure the brain, it suggests that the hypothalamus and hippocampus are damaged, which may be one of the important pathophysiological basis of CNS strain response.