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本文报道用 D-青霉胺治疗原发性胆汁性肝硬化(primary biliary cirrhosis,PBC)87例。全部病人经肝试验均提示有胆汁郁积,线粒体抗体阳性(滴度≥1:10),胆管造影肝外胆管正常。病人随机分为治疗组(55例)及安慰剂组(32例)。青霉胺剂量在8～10周中从150mg/d 增至维持量600mg/d。全部病例每月注射1次 Vit A、D、K。如搔痒明显,必要时加用消胆胺。每3个月检查1次病情、血液学指标、肝试验及免疫球蛋白,可能时在第12和24个月,以后每隔2年进行1次肝活检及肝铜测定。
This article reports 87 cases of primary biliary cirrhosis (PBC) treated with D-penicillamine. All patients were prompted by liver tests have cholestasis, positive for mitochondrial antibodies (titer ≥ 1: 10), cholangiography extrahepatic bile duct normal. Patients were randomly divided into treatment group (55 cases) and placebo group (32 cases). Penicillamine dose was increased from 150 mg / day to maintenance dose of 600 mg / day in 8 to 10 weeks. All cases were injected once a month Vit A, D, K. If itching is obvious, if necessary, add cholestyramine. Check the condition, hematological indicators, liver tests and immunoglobulins every 3 months. Liver biopsy and hepatobiliary tests should be performed once every 2 years when possible after 12 and 24 months when possible.