测定脑出血患者静脉血浆和颅内血肿液中血管活性肠肽 (VIP)、降钙素基因相关肽 (CGRP)含量的变化 ,发现脑出血患者静脉血浆VIP含量无显著改变 ,颅内血肿液VIP含量显著低于静脉血浆VIP含量 ;脑出血患者静脉血浆CGRP含量显著高于对照组 ,不同时期 ( <6h ,6h～ 72h ,>72h)血浆及颅内血肿液CGRP含量比较 ,<6h含量最高 ,此后呈下降趋。本研究结果表明 ,VIP和CGRP参与了脑出血后脑循环改变的病理生理过程 ,尤其是参与了占位初始所致的局部脑损害过程 The content of vasoactive intestinal peptide (VIP) and calcitonin gene related peptide (CGRP) in venous plasma and intracranial hematoma of patients with intracerebral hemorrhage was measured. There was no significant change of VIP content in venous plasma of patients with intracerebral hemorrhage. VIP The content of CGRP in venous plasma of patients with cerebral hemorrhage was significantly higher than that of the control group. The content of CGRP in plasma and intracranial hematoma fluid in different periods (<6h, 6h ~ 72h,> 72h) Since then declined. The results of this study show that VIP and CGRP are involved in the pathophysiological process of cerebral circulation changes after intracerebral hemorrhage, especially involved in the process of local brain damage caused by occupancy