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目的探讨肝胰十二指肠联合移植术治疗1例原发性肝癌合并胰头转移的疗效。方法2004年9月,对1例原发性肝癌合并胰头转移的患者行病肝、全胰腺十二指肠、远端胃及脾脏切除后,进行肝胰十二指肠原位器官簇移植。结果移植术后胰腺功能恢复正常,未应用胰岛素维持;术后1周肝功能恢复正常。患者目前已存活5个月,肝脏和胰腺功能均正常,未发生排斥反应,未见肿瘤复发迹象,一般情况好。结论肝胰十二指肠器官簇移植为上腹部晚期恶性肿瘤患者提供了延长生命的机会,同时更为晚期肝病伴有胰腺功能不良患者的彻底治愈探索出新的手术术式。
Objective To investigate the curative effect of hepatic and pancreaticoduodenal transplantation in the treatment of primary hepatocellular carcinoma with pancreatic head metastasis. Methods In September 2004, one case of primary hepatocellular carcinoma with pancreatic head metastasis was treated with diseased liver, pancreas duodenum, distal stomach and spleen. After the resection of the hepatomegaly and duodenum in situ organ clusters . Results Pancreatic function returned to normal after transplantation. Insulin maintenance was not applied. Liver function returned to normal one week after operation. The patient has now survived for 5 months, liver and pancreas function are normal, no rejection occurred, no signs of tumor recurrence, the general situation is good. Conclusions Cluster transplantation of hepatopancreas and duodenal organs provides a chance to prolong life in patients with advanced malignant tumors of the upper abdomen. At the same time, new surgical procedures are explored for the complete cure of patients with advanced liver disease associated with pancreatic dysfunction.