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目的评价蚓激酶胶囊联合小剂量阿司匹林治疗缺血性脑血管病后遗症的疗效和安全性。方法将106例患者根据简单随机抽样法分为治疗组和对照组各53例。治疗组给予蚓激酶胶囊2粒(60万U),tid,加服阿司匹林75mg,po,qd;对照组给予阿司匹林75mg,po,qd,连用8周。观察用药前后血液流变学指标(全血高切黏度、低切黏度、血浆黏度、血浆纤维蛋白原水平)及疗效。结果治疗后治疗组总有效48例(90.57%),对照组总有效41例(77.36%),明显高于对照组,差异有统计学意义(P<0.05)。两组治疗后血液流变学指标均明显下降(P<0.05或P<0.01),治疗组较对照组下降更明显。结论蚓激酶胶囊能有效改善血液流变学,治疗缺血性脑血管病后遗症疗效较好,不良反应较少。
Objective To evaluate the efficacy and safety of lumbrokinase capsules in combination with low-dose aspirin in the treatment of sequelae of ischemic cerebrovascular disease. Methods 106 patients were divided into treatment group and control group according to simple random sampling method in 53 cases. The treatment group was given lumbrokinase capsules 2 (600000U), tid, plus aspirin 75mg, po, qd; control group given aspirin 75mg, po, qd, once every 8 weeks. The indexes of hemorheology (high shear viscosity, low shear viscosity, plasma viscosity and plasma fibrinogen level) before and after treatment were observed and the curative effect was observed. Results After treatment, the total effective rate was 48 (90.57%) in the treatment group and 41 (77.36%) in the control group, which was significantly higher than that in the control group (P <0.05). After treatment, the indexes of hemorheology were significantly decreased (P <0.05 or P <0.01), and the treatment group was more obvious than the control group. Conclusion Lumbrokinase capsule can effectively improve hemorrheology, the curative effect of treating sequelae of ischemic cerebrovascular disease is better, and adverse reactions are less.