目的：建立中国人右美沙芬（ＤＭ）氧化代谢多态性的表型分型．方法：１２０名无血缘关系的中国人口服ＤＭ２０ｍｇ后，测定其尿中ＤＭ及其代谢物右啡烷（ＤＸ）浓度，并计算代谢比值（ＭＲ）．结果：氧化代谢缺陷率为０８％（１人）；快代谢者可明显区分为极快代谢者（７６人）和中速代谢者（４３人）．０－８ｈ内ＤＭ和ＤＸ的尿排百分率分别为０４％±ｓ０５％和２６％±ｓ１３％，但两者无性别差异．结论：右美沙芬代谢的表型分型为中国人异喹胍４位羟化（ＣＹＰ２Ｄ６）多态性提供了新的信息． Objective: To establish a phenotype of oxidative metabolism polymorphism of dextromethorphan (DM) in Chinese. Methods: 120 unrelated Chinese were treated with oral DM 20 mg and their DM and its metabolite dextrorphan (DX) concentrations were measured and the metabolic ratio (MR) was calculated. Results: The rate of oxidative metabolism was 08% (1 person); those with fast metabolism could be obviously divided into those with fast metabolism (76 people) and those with medium speed metabolism (43 people). The percentage of DM and DX urination in 0-8h was 04% ± s05% and 26% ± s13% respectively, but there was no gender difference between them. CONCLUSION: The phenotypic classification of dextromethorphan metabolism provides new information for Chinese 4-hydroxylation of isoquoin (CYP2D6) polymorphism.