论文部分内容阅读
目的：研究可吸收止血敷料的细胞毒性和遗传毒性，为临床应用的安全性提供依据。方法：应用细胞培养法、Ａｍｅｓ试验和显性致死试验对可吸收止血敷料进行细胞毒性和致突性研究。结果：可吸收止血敷料对Ｌ９２９细胞增殖的影响：细胞相对增殖率４ｄ时为５５．８５％，７ｄ时为１００．１３％；对细胞的形态发育基本没有影响。Ａｍｅｓ试验和显性致死试验均为阴性。结论：可吸收止血敷料未显示对细胞的毒性和致突性，临床应用较为安全。
Objective: To study the cytotoxicity and genotoxicity of absorbable hemostatic dressing and provide the basis for the safety of clinical application. Methods: Cytotoxicity and mutagenicity of absorbable hemostatic dressing were studied by cell culture method, Ames test and dominant lethality test. Results: Absorbable hemostatic dressing on the proliferation of L 929 cells: the relative proliferation rate of cells at 4d was 55.85%, 100d after 7d; basically did not affect the morphological development of cells. Ames test and dominant lethal test were negative. Conclusion: Absorbable hemostatic dressing does not show cytotoxicity and mutagenicity, and its clinical application is safe.