青霉素类抗生素因高效、低毒,临床应用十分广泛,但其过敏反应发生率居各类药物之首,引起其过敏反应的原因和机理十分复杂。除青霉素分子结构原因外,青霉素在生产、储运过程中可能会残留或产生一些杂质,有些极微量杂质即可引起过敏反应[1,2]。本文对1例皮试阴性、曾多次使用青霉 Penicillins antibiotics due to high efficiency, low toxicity, clinical application is very wide, but the incidence of allergic reactions among the first of various drugs, the cause and mechanism of allergic reactions caused by it is very complicated. In addition to the molecular structure of penicillin, penicillin in the production, storage and transportation process may have some impurities or impurities, some trace impurities can cause allergic reactions [1,2]. In this paper, a skin test negative, have repeatedly used Penicillium