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目的 探讨血管紧张素转换酶 (ACE)基因多态性和脑出血发病的关系。方法 应用 PCR方法检测82例脑出血患者和 86例健康者 ACE基因的缺失 /插入多态性。结果 脑出血患者的 DD基因型及 D等位基因频率和正常对照组比较差异有显著意义 ;伴高血压的脑出血患者的 DD基因型和 D等位基因频率明显高于无高血压的脑出血患者 ;无高血压史的脑出血患者的 DD基因型和 D等位基因频率明显高于正常对照组 ;DD基因型和 D等位基因频率与性别、有无糖尿病、高脂血症及吸烟无关。结论 DD基因型和 D等位基因携带者具有脑出血易感性 ,这种易感性不依赖于高血压
Objective To investigate the relationship between angiotensin converting enzyme (ACE) gene polymorphism and the incidence of cerebral hemorrhage. Methods The deletion / insertion polymorphism of ACE gene was detected by PCR in 82 patients with cerebral hemorrhage and 86 healthy controls. Results The frequencies of DD genotypes and D allele in patients with ICH were significantly different from those in controls. The frequencies of DD genotypes and D allele were significantly higher in those with ICH than those without ICH Patients; patients with no history of hypertension had a higher frequency of DD genotypes and D alleles than those of normal controls; DD genotypes and D allele frequencies were not related to gender, presence or absence of diabetes, hyperlipidemia and smoking . Conclusion DD genotype and D allele carriers have the predisposition to cerebral hemorrhage, and the susceptibility does not depend on hypertension