缺血性脑损伤的发生机制目前尚未明确,临床缺乏有效的治疗手段。对ATP敏感性钾通道的研究主要集中于各种组织的缺血及预适应或缺血再灌注的细胞保护方面。研究发现,ATP敏感性钾通道在缺血性脑损伤的病理生理过程中具有重要的作用。本文对该通道的分子结构、在神经系统内的分布、调控机制、相关药物的作用机制和药理学原理、以及其在缺血性脑损伤中的作用机制进行详细的介绍。 The pathogenesis of ischemic brain injury is not yet clear, the clinical lack of effective treatment. Studies of ATP-sensitive potassium channels have focused on the ischemic and preconditioning or cytoprotective aspects of ischemia-reperfusion in various tissues. The study found that ATP-sensitive potassium channels in the pathophysiology of ischemic brain injury has an important role. In this paper, the molecular structure of the channel, the distribution in the nervous system, regulatory mechanisms, the mechanism of action of relevant drugs and pharmacology, as well as its mechanism of action in ischemic brain injury are described in detail.