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目的:研究中药灌肠和口服美沙拉嗪对溃疡性结肠炎(Ulcerative colitis,UC)患者血小板功能的影响。方法:选择2013年1月至2014年6月我院接受治疗的溃疡性结肠炎患者60例,法随机分为两组,每组30例。观察组患者给予中药灌肠联合口服美沙拉嗪治疗,对照组患者单纯给予口服美沙拉嗪治疗。观察并比较两组患者治疗前后C反应蛋白(CRP)、血沉及血小板计数的变化情况。结果:观察组患者总有效率显著高于对照组,差异有统计学意义(P<0.05)。两组患者治疗前CRP、血沉、血小板计数等指标差异无统计学意义(P>0.05)。治疗后,观察组CRP、血沉及血小板计数显著低于对照组,差异有统计学意义(P<0.05)。结论:中药保留灌肠加口服美沙拉嗪肠溶片用于治疗UC,可较好地改善患者症状,增大疗效,改善其血小板功能状态。值得推荐。
Objective: To study the effects of enema and oral mesalazine on platelet function in patients with ulcerative colitis (UC). Methods: Sixty patients with ulcerative colitis treated in our hospital from January 2013 to June 2014 were randomly divided into two groups (n = 30 in each group). Patients in the observation group were given enema of traditional Chinese medicine combined with oral mesalazine, and patients in the control group were treated with oral mesalamine alone. The changes of C-reactive protein (CRP), erythrocyte sedimentation rate and platelet count before and after treatment were observed and compared between two groups. Results: The total effective rate in observation group was significantly higher than that in control group, the difference was statistically significant (P <0.05). The two groups of patients before treatment CRP, ESR, platelet count and other indicators no significant difference (P> 0.05). After treatment, the observation group CRP, ESR and platelet count was significantly lower than the control group, the difference was statistically significant (P <0.05). Conclusion: The traditional Chinese medicine retention enema plus oral mesalazine enteric-coated tablets for the treatment of UC, can better improve the symptoms of patients, increase the curative effect and improve the platelet functional status. Recommended.