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谷胱甘肽S-转移酶系(GSTs)是由多个基因编码,具有多种功能的超家族酶,是多种生物体内的主要解毒系统,它催化还原型谷胱甘肽(GSH)与多种亲电子化合物结合,使其还原、功能失活,最终排出体外。近年来研究发现,GSTs酶系以多种毒性物质、活性氧(ROS)及其产物作为底物,进行生物转化代谢,在肺部的抗氧化过程中起重要作用,参与哮喘发作过程中的氧化/抗氧化调节,与哮喘的发病密切相关。由于GSTs的基因多态性改变了酶蛋白活性而与哮喘遗传易感性密切相关。本文综述了GSTs分型、结构、底物及其与哮喘的关系。
Glutathione S-transferase (GSTs) is a superfamily enzyme encoded by multiple genes and has multiple functions. It is the major detoxification system in many organisms and catalyzes the reduction of glutathione (GSH) and A variety of electrophilic compounds combine to make it restore, function inactivation, and ultimately excreted. In recent years, the study found that GSTs enzyme system with a variety of toxic substances, reactive oxygen species (ROS) and their products as a substrate for biotransformation and metabolism, play an important role in the lung antioxidant process, involved in the oxidation process of asthma attack / Antioxidant regulation, and the incidence of asthma are closely related. GSTs genetic polymorphisms change the enzyme activity and genetic susceptibility to asthma are closely related. This article reviews GSTs typing, structure, substrate and its relationship with asthma.