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目的:通过meta分析，探讨慢性肾脏病患者血管钙化的危险因素，为临床早期识别、预防该病提供循证医学依据，进而改善慢性肾脏病患者的预后。方法:检索知网、万方、维普、中国生物医学文献服务系统、Pubmed、Embase、Cochrane、Web of Science数据库，筛选慢性肾脏病患者血管钙化危险因素的相关文献，运用Revman 5.3软件对纳入的文献进行meta分析。结果:最终纳入36篇符合要求的文献，总样本量17 969例，狼疮脑病的发生率为35.7%。meta分析结果显示，各危险因素的合并比值比(n OR)及95%可信区间(n CI)分别为：高血钙3.74(2.47～5.65)，高血磷1.45(1.28～1.65)，钙磷乘积1.13(1.04～1.23)，C反应蛋白升高1.88(1.43～2.46)，估测肾小球滤过率下降0.87(0.86～0.87)，成纤维细胞生长因子-23升高1.53(1.28～1.82)，高血压病史1.14(1.10～1.17)，糖尿病史1.36(1.24～1.49)，高龄1.05(1.04～ 1.06)，高脂血症0.98(0.97～0.99)，男性1.20(1.09～1.33)。n 结论:高血钙、高血磷、高成纤维细胞生长因子-23、高血压病、糖尿病、高龄是慢性肾脏病患者发生血管钙化的重要危险因素。“,”Objective:To analyze the risk factors of vascular calcification in patients with chronic kidney disease (CKD), and to provide evidence-based medical evidence for early clinical diagnosis and prevention of CKD, and to improve the prognosis of CKD patients.Methods:To screen vascular calcification risk factors in patients with CKD, we searched Pubmed, Embase, Cochrane, Web of Science databases, and searched literature on vascular calcification risk factors in patients with vascular calcification. The Revman 5.3 software was used for meta-analysis of the literature.Results:The total sample size was 17 969. The incidence of lupus encephalopathy was 35.7%. The combined odds ratio(n OR) values and 95% confidence interval (n CI) were: elevated serum calcium 3.74 (2.47-5.65), elevated serum phosphorus 1.45 (1.28-1.65), calcium phosphorus product 1.13 (1.04- 1.23), elevated C-reactive protein 1.88 (1.43-2.46), decreased evaluated glamerular filrotion rate 0.87 (0.86~0.87), elevated fibroblast growth factor (FGF)-23 1.53 (1.28-1.82), hypertension 1.14 (1.10-1.17), diabetes 1.36 (1.24-1.49), advanced age 1.05 (1.04-1.06), hyperlipidemia 0.98 (0.97-0.99), male 1.20 (1.09-1.33).n Conclusions:High blood calcium, high blood phosphorus, high FGF-23, hypertension, diabetes, and advanced age were important risk factors for vascular calcification in patients with CKD.