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在蟾蜍坐骨神经－缝匠肌标本上进行细胞内记录，观察２－氯－４－溴－α－甲基肉桂酸钠盐三个浓度组对神经肌接头电活动的影响。０．１ｍｍｏｌ／Ｌ对肌细胞静息膜电位和终板电位无影响；１ｍｍｏｌ／Ｌ对肌细胞静息电位也没有影响，但使终板电位从１．８８±０．２９ｍＶ减小到０．２６±０．０６ｍＶ（ｎ＝８，ｐ＜０．０１），双脉冲易化作用减弱，甚至抑制；１Ｏｍｍｏｌ／Ｌ使终板电位完全消失，使肌细胞静息膜电位从８２．１３±１．０５ｍＶ降至４８．６３±１．７６ｍＶ（ｎ＝８）。结果表明２－氯－４－溴－α－甲基肉桂酸钠盐对蟾蜍神经肌肉接头传递有阻遏作用，其阻遏作用可能主要是通过突触前机理。
The effects of 2-chloro-4-bromo-α-methylcinnamic acid sodium salt on the electrical activity of neuromuscular junction were observed in the sciatic nerve-sartorius muscle of Toad. 0.1 mmol / L had no effect on the resting membrane potential and the plateau potential of myocytes; 1mmol / L had no effect on the resting potential of myocytes, but decreased the plateau potential from 1.88 ± 0.29mV to 0. 26 ± 0.06mV (n = 8, p <0.01). The facilitation of double-pulse administration was weakened and even inhibited. The plateau potential of 10mmol / L disappeared completely and the resting membrane potential of myocytes increased from 82.13 ± 1 .05mV to 48.63 ± 1.76mV (n = 8). The results showed that 2-chloro-4-bromo-α-methyl cinnamic acid sodium salt on the toads neuromuscular junction transmission has a repressive effect, its repression may be mainly through the presynaptic mechanism.