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目的:探讨单唾液酸四己糖神经节苷脂钠(GMI)对新生儿缺氧缺血性脑病(HIE)的疗效。方法:将172例中、重度HIE患儿随机分为治疗组88例和对照组84例,两组均给予常规治疗,治疗组加用GMI 20 mg/d静脉滴注,疗程10 d。两组患儿由专人对临床症状及体征消失时间进行登记和疗效评估。结果:治疗组与对照组总有效率分别为92.0%和70.2%(χ2=13.49,P<0.05);两组胃肠功能紊乱消失时间(P<0.05)、循环不良消失时间(P<0.01)、意识恢复时间(P<0.01)、神经反射恢复时间(P<0.01)、肌张力恢复时间(P<0.01)比较差异均有统计学意义。结论:在常规治疗基础上加用GMI治疗HIE能有效控制缺氧缺血所致的脑水肿,显著改善患儿临床症状。
Objective: To investigate the effect of monosialotetrahexosyl ganglioside sodium (GMI) on neonatal hypoxic-ischemic encephalopathy (HIE). Methods: A total of 172 children with moderate and severe HIE were randomly divided into treatment group (n = 88) and control group (n = 84). Both groups were given routine treatment. The treatment group was treated with intravenous infusion of GMI 20 mg / d for 10 days. Two groups of children by hand on the clinical symptoms and signs of disappearance of time registration and efficacy evaluation. Results: The total effective rate was 92.0% in treatment group and 70.2% in control group (χ2 = 13.49, P <0.05). The disappearance time of gastrointestinal dysfunction (P <0.05) , Recovery time of consciousness (P <0.01), recovery time of nerve reflex (P <0.01) and recovery time of muscle tone (P <0.01) were statistically significant. Conclusion: GMI combined with conventional therapy can effectively control brain edema caused by hypoxia-ischemia and improve clinical symptoms in children.