【摘 要】
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In this work, hollow manganese dioxide/gold nanoparticle (MnO2/GNPs) hybrid drug nanocarriers were pre-pared by coupling the gold nanoparticles (GNPs) with holl
【机 构】
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Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research, School of Chemistry and Chemical En
论文部分内容阅读
In this work, hollow manganese dioxide/gold nanoparticle (MnO2/GNPs) hybrid drug nanocarriers were pre-pared by coupling the gold nanoparticles (GNPs) with hollow structure manganese dioxide (MnO2). Among them, GNPs have been used as near-infrared (NIR)-responsive element for photothermal effect under NIR laser irradiation. The glutathione (GSH)-responsive and pH-responsive performances of drug release were derived from hollow MnO2. Particularly, Doxorubicin hydrochloride (DOX) can be loaded into hollow MnO2/GNPs with the drug loading efficiency up to 82.0%. Moreover, the photothermal effect and GSH-/pH-responsive properties of hollow MnO2/GNPs were investigated. The hollow MnO2/GNPs possessed satisfactory drug release efficiency (ca. 87.4% of loaded drug released in 12 h) and have high photothermal conversion efficiency, multiresponsive properties, and degradability. Finally, the kinetics of drug release was discussed in detail. Thus, our finding high-lights that the multiresponsive nanocarriers are of great potential in the field of drug controlled release.
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