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双异丙吡胺磷酸盐(达舒平Disopyramide),化学名4-双异丙胺基-2-苯基-2-(2-吡啶基)-丁酰胺,系化学合成的抗心律失常药,其电生理特征与奎尼丁相似,副作用比奎尼丁小,经动物试验与临床应用证明对房性及室性心律失常有较好的疗效。药理作用: 本药有膜抑制及抗胆碱能作用,对心肌浦顷野纤维的电生理效应与奎尼丁相似,具有延长动作电位时间和有效不应期、从而消除折返性心律失常,并有抑制异位节律性的作用。适应症: 各种原因引起的频发房性及室性早搏、室上性及
Disopyramide, a chemical name 4-diisopropylamino-2-phenyl-2- (2-pyridyl) -butyramide, is a chemically synthesized anti-arrhythmic drug, Electrophysiological characteristics similar to quinidine, side effects than quinidine, animal experiments and clinical application of atrial and ventricular arrhythmias proved effective. Pharmacological effects: The drug has membrane inhibition and anticholinergic effects on the cardiopulmonary fibers electrophysiological effects similar to quinidine, with the extension of action potential time and effective refractory period, thereby eliminating reentrant arrhythmias and Inhibit the ectopic rhythm of the role. Indications: a variety of causes of frequent atrial and ventricular premature beats, supraventricular and sexual