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目的探讨肝癌患者细胞免疫功能及肝动脉化疗栓塞术(TACE)对其影响。方法对2005年3月-8月在我科行TACE的肝癌患者于治疗前1天、治疗后1周和2周分别测定外周血T细胞亚群,进行比较,同时采用健康志愿者作为对照组进行治疗前比较。结果治疗前CD3+、CD4+、CD4+/CD8+水平较对照组显著降低,治疗后1周CD3+、CD4+、CD4+/CD8+水平均较治疗前略升高,但无统计学差异。治疗后2周CD3+、CD4+、CD4+/CD8+水平均较治疗前显著升高。结论肝癌患者细胞免疫功能处于抑制状态,TACE对细胞免疫功能影响较小,随着肿瘤负荷减小,细胞免疫功能显著提高。
Objective To investigate the effects of TACE on cellular immunity and hepatic arterial chemoembolization in patients with liver cancer. Methods Peripheral blood T lymphocyte subsets were determined at 1 day, 1 week and 2 weeks after TACE treatment in our hospital from March to August in 2005. The healthy volunteers were used as the control group Before treatment comparison. Results The levels of CD3 +, CD4 + and CD4 + / CD8 + before treatment were significantly lower than those in the control group. The levels of CD3 +, CD4 + and CD4 + / CD8 + in the first week after treatment were slightly higher than those before treatment, but there was no significant difference. The levels of CD3 +, CD4 +, CD4 + / CD8 + in two weeks after treatment were significantly higher than those before treatment. Conclusion The cellular immune function of HCC patients is in a state of inhibition. TACE has little effect on cellular immune function. With the decrease of tumor burden, cellular immune function is significantly increased.