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目的观察肺炎支原体肺炎患儿血清白介素17(IL-17)和白介素23(IL-23)水平变化,并探讨其临床意义。方法选取2013—2014年东南大学医学院附属南京同仁医院收治的肺炎支原体肺炎患儿40例作为观察组,同时选取健康儿童40例作为对照组。观察组患儿入院后进行常规治疗,比较两组儿童治疗前后血清IL-17和IL-23水平及C反应蛋白异常率。结果观察组患儿治疗前血清IL-17和IL-23水平均高于对照组(P<0.05);两组儿童治疗后血清IL-17和IL-23水平比较,差异无统计学意义(P>0.05),且观察组患儿治疗后血清IL-17和IL-23水平均低于治疗前(P<0.05)。观察组患儿治疗前C反应蛋白异常率高于对照组(P<0.05);两组儿童治疗后C反应蛋白异常率比较,差异无统计学意义(P>0.05)。结论检测血清IL-17和IL-23水平对了解肺炎支原体肺炎患儿疾病进展及疗效有一定临床意义,可作为其病情发展、转归的评价指标。
Objective To investigate the changes of serum interleukin 17 (IL-17) and interleukin 23 (IL-23) levels in children with Mycoplasma pneumoniae pneumonia and to explore its clinical significance. Methods Forty children with mycoplasma pneumoniae pneumonia admitted from Nanjing Tongren Hospital affiliated to School of Medicine of Southeast University from 2013 to 2014 were selected as the observation group. Forty healthy children were selected as the control group. Children in observation group were treated routinely after admission. The levels of IL-17 and IL-23 in serum and the abnormal rate of C-reactive protein in children before and after treatment were compared. Results The serum levels of IL-17 and IL-23 in the observation group before treatment were significantly higher than those in the control group (P <0.05). There was no significant difference in serum IL-17 and IL-23 levels between the two groups after treatment > 0.05), and the levels of serum IL-17 and IL-23 in the observation group were lower than those before treatment (P <0.05). The abnormal rate of C-reactive protein in observation group before treatment was higher than that in control group (P <0.05). There was no significant difference in the abnormal rate of C-reactive protein between the two groups after treatment (P> 0.05). Conclusion The detection of serum IL-17 and IL-23 levels in children with Mycoplasma pneumoniae disease progression and efficacy of a certain clinical significance, as its disease development, prognosis evaluation index.