血浆高密度脂蛋白 (HDL)与低密度脂蛋白 (LDL)一样可以在体内外发生氧化修饰 ,引起其理化性质发生一系列的改变 ,如多不饱和脂肪酸过氧化 ,卵磷脂水解 ,蛋白质发生聚合或分解等 .活体内HDL可能在动脉壁巨噬细胞、内皮细胞及中性粒细胞、单核细胞的作用下发生氧化修饰 .氧化修饰HDL可能通过清道夫受体途径代谢 .氧化修饰HDL产生多种致动脉粥样硬化作用 .维生素E、C的摄入可能有助于防止脂蛋白的氧化 Plasma high-density lipoprotein (HDL), like low-density lipoprotein (LDL), undergoes oxidative modification both in vitro and in vivo, resulting in a series of changes in its physico-chemical properties such as polyunsaturated fatty acid peroxidation, lecithin hydrolysis and protein polymerization Or decomposition, etc. In vivo, HDL may be oxidatively modified by arterial wall macrophages, endothelial cells, neutrophils, monocytes, etc. Oxidatively modified HDL may be metabolized through the scavenger receptor pathway. Atherosclerosis induced by vitamin E, C intake may help prevent the oxidation of lipoprotein