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以往的研究表明,青蒿素类抗疟药在较低剂量即可引起外周血网织红细胞减少和骨髓中,幼红细胞成熟障碍,然而迄今未见国内外有关此毒性机理的研究报道。本文用荧光分光光度法测定Beagle犬和大鼠po青蒿琥酯(artesunate)后外周血红细胞游离原卟啉(FEP)的含最变化;用铁染色法观察犬外周血和骨髓涂片中的幼红细胞的铁颗粒沉积情况;在电镜下观察犬骨髓幼红细胞超微结构改变并对线粒体中沉积颗粒进行X射线微区元素分析;同时测定青蒿琥酯钠对离体大鼠肝线粒体亚铁螯合酶(ferrochelatase)活性的影响。结果表明青蒿琥酯
Previous studies have shown that artemisinin-based antimalarial drugs can cause peripheral blood reticulocyte reduction and immature erythrocyte maturation in lower doses at low doses. However, no studies on this toxic mechanism have been reported at home and abroad so far. Fluorescence spectrophotometry was used to determine the most change of peripheral erythrocyte free protoporphyrin (FEP) in Beagle dogs and rats after artesunate. Erythrocyte deposition of iron particles; electron microscopic observation of canine bone marrow erythrocyte ultrastructure changes and mitochondrial sediment particles X-ray microelement analysis; simultaneous determination of artesunate sodium on isolated rat liver mitochondrial ferrous Effect of ferrochelatase activity. The results show artesunate