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目的分析该院住院部药房2015年口服降糖药物的临床使用情况,为临床合理用药提供参考。方法选取医院2015年治疗糖尿病处方3 000张,降糖药物有13个品种,按照WHO推荐的限定日剂量(DDD)、用药频度(DDDs)、药物利用指数(DUI)对选定的降糖药物进行统计分析。结果 3 000张处方中,口服降糖药物有13个品种,具体分为5大类:磺酰脲类、双胍类、α-糖苷酶抑制剂、胰岛素促泌剂、胰岛素增效剂。双胍类日销量金额比率为28.59%,α-糖苷酶抑制剂为21.28%,磺酰脲类19.90%,占居前3位。盐酸二甲双胍肠溶胶囊、阿卡波糖片、格列吡嗪片DDDs占居前3位,各药DUI均<1.0,用药均合理。结论口服降糖药物种类供应齐全,且用药合理,双胍类、α-糖苷酶抑制剂、磺酰脲类使用广泛,且趋于稳定,为临床合理用药提供参考。
Objective To analyze the clinical use of oral hypoglycemic agents in pharmacies of inpatient department of the hospital in 2015 and provide references for clinical rational drug use. Methods A total of 3 000 prescriptions for diabetes mellitus and 13 hypoglycemic agents were selected in the hospital in 2015. According to the DDD, DDDs and DUI recommended by WHO, Drugs for statistical analysis. Results Of the 3 000 prescriptions, there were 13 varieties of oral hypoglycemic agents, which were divided into 5 categories: sulfonylureas, biguanides, α-glucosidase inhibitors, insulin secretagogues and insulin synergists. The daily sales amount of biguanide was 28.59%, that of α-glycosidase inhibitor was 21.28%, and that of sulfonylureas was 19.90%, accounting for the top three. Metformin hydrochloride enteric-coated capsules, acarbose tablets, glipizide tablets DDDs accounted for the top three, each drug DUI <1.0, medication is reasonable. Conclusion The supply of oral hypoglycemic drugs is complete, and the drugs are reasonable. The biguanides, α-glucosidase inhibitors and sulfonylureas are widely used and stable, providing reference for clinical rational drug use.