【摘 要】
:
Autophagy plays an important role in the development and pathogenesis of various diseases.It can be induced by a variety of events such as hypoxia,nutrient-starvation,and mechanical damage.Many neurological disorders such Parkinson\'s disease,Alzheimer
【机 构】
:
Department of Orthopedics, Zhongshan Hospital, Fudan University, Shanghai 200032, China;Department o
论文部分内容阅读
Autophagy plays an important role in the development and pathogenesis of various diseases.It can be induced by a variety of events such as hypoxia,nutrient-starvation,and mechanical damage.Many neurological disorders such Parkinson\'s disease,Alzheimer\'s disease,amyotrophic lateral sclerosis,Huntington\'s disease,cerebral ischemia,and acute spinal cord injury (ASCI),are closely related to autophagy.However,therapeutic strategies to manipulate autophagy have not yet been fully deciphered due to the limited knowledge of the molecular mechanisms underlying autophagy in these disorders.
其他文献
Ischemic stroke is a leading cause of morbidity and mortality worldwide.Resident microglia are the principal immune cells of the brain,and the first to respond to the pathophysiological changes induced by ischemic stroke.Traditionally,it has been thought
Alzheimer\'s disease (AD) is a devastating neurodegenerative disease and the most common form of dementia in the elderly.Concurrent with an aging population,the incidence of AD has been rising steadily and become a global threat to public health [1].Unf
Syncope is defined as a transient loss of consciousness due to global cerebral hypoperfusion,accompanied by loss of muscle tone and failure to maintain an active position.Vasovagal syncope (VVS) is the most common presentation of syncope,and its diagnosti
A central objective in deciphering the nervous system in health and disease is to define the connections of neurons.The propensity of neurotropic viruses to spread among synaptically-linked neurons makes them ideal for mapping neural circuits.So far,sever
MicroRNA-132 (miR-132),a small RNA that regulates gene expression,is known to promote neurogenesis in the embryonic nervous system and adult brain.Although exposure to psychoactive substances can increase miR-132 expression in cultured neural stem cells (
Recent studies have shown that the chemokine receptor CXCR3 and its ligand CXCL10 in the dorsal root ganglion mediate itch in experimental allergic contact dermatitis (ACD).CXCR3 in the spinal cord also contributes to the maintenance of neuropathic pain.H
ETS-1 is a transcription factor that is a member of the E26 transformation-specific (ETS) family.Galanin receptor 2 (GalR2),a subtype of receptors of the neuropeptide galanin,has been shown to have an antidepressant-like effect after activation in rodents
Neuroligins (NLs) are postsynaptic cell-adhesion proteins that play important roles in synapse formation and the excitatory-inhibitory balance.They have been associated with autism in both human genetic and animal model studies,and affect synaptic connect
The locus coeruleus (LC) has been studied in major depressive disorder (MDD) and bipolar disorder (BD).A major problem of immunocytochemical studies in the human LC is interference with the staining of the immunocytochemical end-product by the omnipresent
Previous work has demonstrated that the sensitization of spinal neurons and microglia is important in the development of pain behaviors induced by BmK Ⅰ,a Na+ channel activator and a major peptide component of the venom of the scorpion Buthus martensi Kar