【摘 要】
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Autophagy plays an important role in the development and pathogenesis of various diseases.It can be induced by a variety of events such as hypoxia,nutrient-starvation,and mechanical damage.Many neurological disorders such Parkinson\'s disease,Alzheimer
【机 构】
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Department of Orthopedics, Zhongshan Hospital, Fudan University, Shanghai 200032, China;Department o
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Autophagy plays an important role in the development and pathogenesis of various diseases.It can be induced by a variety of events such as hypoxia,nutrient-starvation,and mechanical damage.Many neurological disorders such Parkinson\'s disease,Alzheimer\'s disease,amyotrophic lateral sclerosis,Huntington\'s disease,cerebral ischemia,and acute spinal cord injury (ASCI),are closely related to autophagy.However,therapeutic strategies to manipulate autophagy have not yet been fully deciphered due to the limited knowledge of the molecular mechanisms underlying autophagy in these disorders.
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