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本文报道用异搏停防治60只家兔急性心肌梗塞的实验研究。结果发现,结扎冠状动脉3小时后,心肌细胞膜发生明显退变,线粒体基质内出现直径为0.20～0.23μm的球形颗粒。异搏停对急性心肌梗塞起保护作用,以6小时内最为明显。心肌梗塞区钙含量比非梗塞区高2倍,分别为1.496±0.640和0.720±0.266μg、mg(p<0.001),这与心肌梗塞区与非梗塞区的线粒体基质内电子密度和钙含量大小颗粒结构是一致的。
This article reports the use of verapamil to prevent 60 rabbits with acute myocardial infarction experimental study. The results showed that 3 hours after ligation of the coronary artery, myocardial cell membrane degeneration significantly, mitochondrial matrix appeared within the diameter of 0.20 ~ 0.23μm spherical particles. Verapamil to protect acute myocardial infarction, the most obvious within 6 hours. The calcium content of myocardial infarction area was 2 times higher than that of non-infarction area, which were 1.496 ± 0.640 and 0.720 ± 0.266μg, mg (p <0.001), which were related to the electron density and calcium content in mitochondria matrix in myocardial infarction area and non-infarction area The particle structure is consistent.