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目的:观察还原型谷胱甘肽联合舒血宁对于恶性肿瘤患者接受化疗时并发药物性肝损害的治疗作用。方法:选取2011年3月-2013年3月茂名市石化医院收治的化疗后出现药物性肝损害的患者112例,随机分为治疗组与对照组,治疗组58例,予以还原型谷胱甘肽联合舒血宁注射液治疗;对照组54例,予以还原型谷胱甘肽注射液治疗,观察比较两组患者治疗肝损害的疗效。结果:2周后,总有效率治疗组为89.7%,对照组为68.5%,两组总有效率比较,差异有统计学意义(P<0.05)。治疗组显效率63.8%也明显高于对照组46.3%,差异有统计学意义(P<0.05),结论:还原型谷胱甘肽、舒血宁两药联合有协同作用,对恶性肿瘤患者化疗药物性肝损害有较好的治疗作用。
Objective: To observe the therapeutic effect of reduced glutathione combined with Shuxuening on patients with malignant tumor undergoing concurrent chemotherapy-induced liver injury. Methods: One hundred and twelve patients with drug-induced liver injury after chemotherapy were selected from March 2011 to March 2013 in the Petrochemical Hospital of Maoming City. They were randomly divided into treatment group and control group. The treatment group received 58 cases of glutathione Peptide combined with Shuxuening injection; control group of 54 patients, treated with reduced glutathione injection, the treatment of liver damage in two groups were observed and compared. Results: After 2 weeks, the total effective rate was 89.7% in the treatment group and 68.5% in the control group. The total effective rate was statistically significant (P <0.05). The effective rate of treatment group was 63.8%, which was significantly higher than that of control group (46.3%), the difference was statistically significant (P <0.05). Conclusion: The combination of reduced glutathione and Shuxuening have synergistic effects on the chemotherapy of malignant tumor patients Drug-induced liver damage have a better therapeutic effect.