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本文比较了钙拮抗剂硝苯吡啶与尼群地平对慢性充血性心力衰竭(CHF)的临床疗效。结果发现,两药显效率及总有效率相似。两药均使血浆血管紧张素Ⅱ(AngⅡ)、醛固酮(ALD)及肌红蛋白(Mb)水平下降。硝苯吡啶能增加血浆肾素活性(PRA),尼群地平则使PRA 降低。
This article compared the clinical effects of the nifedipine and nitrendipine on chronic congestive heart failure (CHF). The results showed that the two drugs were effective and the total effective rate is similar. Both drugs decreased the levels of plasma angiotensin Ⅱ (AngⅡ), aldosterone (ALD) and myoglobin (Mb). Nifedipine increased plasma renin activity (PRA) and nitrendipine reduced PRA.