【摘 要】
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Dear Editor,The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) plays a crucial role in human antioxidant defense response against envir
【机 构】
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Center for Regenerative and Translational Medicine, Guangdong Provincial Academy of Chinese Medical
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Dear Editor,The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) plays a crucial role in human antioxidant defense response against environmental insults.Small molecular chemical activators of Nrf2 can confer protection against oxidative insults and inhibit the progression of diseases related to oxidative stress.Here,we identified obacunone as a novel activator of Nrf2 by decreasing Nrf2 ubiquitination and increasing its stability.In support of these findings,the systemic administration of obacunone strongly inhibits bleomycin-induced lung fibrosis in mice.Therefore,obacunone may also provide antioxidant protection for humans against tissue damage caused by oxidative insults.
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