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目的：探讨食管鳞状细胞癌（ESC）组织中nm23、p53蛋白表达及其意义。方法：应用免疫组织化学方法检测63例ESC癌组织中nm23、p53蛋白表达。结果：nm23蛋白表达与淋巴结转移呈负相关，与病理分级、病理分期无关。P53蛋白表达与病理分级、病理分期及淋巴结转移无关。两蛋白表达不存在相关性。nm23阳性、p53阴性，生存期明显长于nm23阴性、p53阳性或其它组合者。结论：nm23低表达在ESC淋巴结转移中起重要作用；nm23、p53基因在ESC癌变与转移过程可能不相关；联合检测nm23和p53蛋白表达对临床判断预后有一定价值。
Objective: To investigate the expression of nm23 and p53 proteins in esophageal squamous cell carcinoma (ESC) and its significance. Methods: Immunohistochemistry was used to detect the expression of nm23 and p53 in 63 ESC tissues. RESULTS: The expression of nm23 protein was negatively correlated with lymph node metastasis, and was not related to pathological grade or pathological stage. The expression of P53 protein was not associated with pathological grade, pathological stage and lymph node metastasis. There is no correlation between the two protein expressions. Nm23 positive, p53 negative, survival was significantly longer than nm23 negative, p53 positive or other combinations. Conclusion: The low expression of nm23 plays an important role in lymph node metastasis of ESC; nm23 and p53 genes may not be involved in the process of ESC metastasis and metastasis; combined detection of nm23 and p53 protein has a certain value in clinical judgment of prognosis.