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皮肤T淋巴细胞瘤是一种显著亲表皮组织的T辅助细胞恶性肿瘤。这种病可起源于皮肤经表皮自然迁移的正常T辅助细胞的恶性转变而来。恶变的T细胞分裂形成恶性T辅助细胞的克隆,起初保留了正常T细胞前体的特性,包括表现型,功能和转归型。当疾病发展时可出现更恶性的细胞,表面抗原发生改变,并失去亲表皮性。这些瘤细胞可出现在真皮下层,带有活化抗原或其他与增生相关的抗原,并能扩散到内脏器官。已从单克隆抗体的研究获得了支持皮肤T淋巴细胞瘤个体发生解释的证据。
Cutaneous T-cell lymphoma is a T-helper malignancy of the pro-epidermal tissue. This disease can originate from the malignant transformation of normal T helper cells that naturally migrate through the epidermis. Malignant T cells divide to form clones of malignant T helper cells, initially retaining the characteristics of normal T cell precursors, including phenotype, function, and prognosis. When the disease develops more malignant cells, surface antigen changes, and loss of pro-epidermal properties. These tumor cells can appear in the subdermal layer, with activated antigens or other proliferative-related antigens, and can spread to the internal organs. Evidence of support for the interpretation of cutaneous T-cell tumors has been obtained from monoclonal antibody studies.